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用雌激素处理妊娠兔可使胎肺洗出液和洗出的肺组织磷脂含量及组成产生明显变化。磷脂总量及磷脂胆硷(卵磷脂)浓度增加,而神经鞘磷脂浓度降低。这些变化使得肺表面活性物质产生增加,因而胎肺成熟。现认为新生儿原发性呼吸窘迫综合征是由于缺乏表面活性物质。因为雌激素能增加表面活性物质,所以考虑用它作为预防和/或治疗新生儿呼吸窘迫综合征的一种可供选择的方法。为了解雌激素对其他含磷的重要生命器官——如脑的影响,作者研究了给妊娠兔注射雌激素对胎脑脂类含量的影响。
Treatment of pregnant rabbits with estrogen can cause significant changes in the phospholipid content and composition of fetal lung eluate and lung tissue washed out. Total phospholipids and phospholipid choline (lecithin) concentration increased, while sphingomyelin concentration decreased. These changes result in increased pulmonary surfactant production and hence fetal lung maturation. Now that the neonatal primary respiratory distress syndrome is due to the lack of surfactant. Because estrogen increases surface-active substances, it is considered as an alternative to preventing and / or treating neonatal respiratory distress syndrome. To understand the effect of estrogen on other important vital organs that contain phosphorus, such as the brain, the authors investigated the effect of injecting estrogen in pregnant rabbits on fetal brain lipid levels.