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目的 研究血管紧张素 - 1转换酶 ( ACE- 1)基因多态性与缺血性脑卒中 ( IS)的关系。方法 运用多聚酶链反应 ( PCR)技术检测 143例 IS及 15 4例对照组患者 ACE- 1基因多态性。结果 IS组 ACE- 1基因 DD基因型和 D等位基因与对照组比较差异无统计学意义 ;重型组 ID基因型与对照组相比有统计学意义 ,D等位基因与临床IS相关。结论 ACE- 1基因 ID基因型可能是 IS危险因子 ,ID基因型与重型 IS有关。
Objective To investigate the relationship between angiotensin-1 converting enzyme (ACE-1) gene polymorphism and ischemic stroke (IS). Methods Polymerase chain reaction (PCR) was used to detect ACE-1 gene polymorphism in 143 cases of IS and 154 cases of control group. Results There was no significant difference in DD genotypes and D allele between ACE gene and D allele of IS group compared with control group. ID genotype of severe group was statistically significant compared with control group, and D allele was correlated with clinical IS. Conclusion ACE-1 gene ID genotype may be IS risk factor, ID genotype and heavy IS.