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目的:测定胃癌患者血清中糖链抗原19-9(CA19-9)、糖链抗原24-2(CA24-2)、糖链抗原72-4(CA72-4)的水平,探讨CA19-9、CA24-2、CA72-4在胃癌不同病程分期中的临床意义。方法:采用电化学发光法分别测定65例正常对照组、69例良性胃病组、157例胃癌患者血清中CA19-9、CA24-2、CA72-4的含量,组间采用SPSS13.0统计软件对数据进行分析处理。结果:血清中CA19-9、CA24-2、CA72-4水平与诊断阳性可随胃癌的TNM分期递增而明显升高。不同病程分期的胃癌患者血清CA19-9、CA24-2、CA72-4差异有统计学意义(P<0.05)。血清CA19-9、CA24-2、CA72-4水平与胃癌分化程度具有统计学意义(P<0.05;r=0.7243;r=0.8701;r=0.9213)。结论:不同病程分期胃癌患者血清中CA19-9、CA24-2、CA72-4的水平具有显著性差异,与胃癌分化程度有关,癌组织分期越高、分化程度越差血清CA19-9、CA24-2、CA72-4的水平越高。血清CA19-9、CA24-2、CA72-4的水平变化对判断进展期胃癌病情演变、疗效及预后具有临床意义。
Objective: To determine the serum levels of glyco antigen 19-9 (CA19-9), glyco antigen 24-2 (CA24-2) and carbohydrate antigen 72-4 (CA72-4) in patients with gastric cancer, Clinical Significance of CA24-2 and CA72-4 in Different Stages of Stomach Cancer. Methods: The levels of serum CA19-9, CA24-2 and CA72-4 in 65 normal controls, 69 benign gastric diseases and 157 gastric cancer patients were determined by electrochemiluminescence. SPSS13.0 software was used to measure the serum levels of CA19-9, Data analysis and processing. Results: Serum CA19-9, CA24-2, CA72-4 levels and diagnostic positive with gastric cancer TNM staging increased significantly increased. The difference of serum CA19-9, CA24-2 and CA72-4 in gastric cancer patients with different stages of disease was statistically significant (P <0.05). Serum CA19-9, CA24-2, CA72-4 levels and gastric cancer differentiation was statistically significant (P <0.05; r = 0.7243; r = 0.8701; r = 0.9213). Conclusion: The levels of serum CA19-9, CA24-2 and CA72-4 in patients with staging gastric cancer with different stages of disease have significant differences, which are related to the degree of differentiation of gastric cancer. The higher the stage of cancer, the worse the differentiation is, the higher the serum levels of CA19-9, CA24- 2, the higher the level of CA72-4. Serum CA19-9, CA24-2, CA72-4 level changes in the diagnosis of advanced gastric cancer progression, efficacy and prognosis of clinical significance.