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目的:研究癌变肠道局部卟啉浓度差异并阐述其在自体荧光光谱诊断中的应用。方法:检测30例大肠癌病人,30例正常人血原卟啉Ⅸ浓度差异,以及60例大肠组织(30例正常;30例异常)原卟啉Ⅸ的含量。结果:癌症病人血液中血原卟啉IX明显高于正常人(P<0.05),大肠癌组织原卟啉IX含量大于大肠正常组织的含量(P<0.05)。结论:癌变肠道局部卟啉含量异常升高,是大肠早期癌症自体荧光诊断技术(644.3±5.7)nm处特异荧光峰值的物质基础。
Objective: To study the difference of local porphyrin concentration in the intestine of cancer and its application in the diagnosis of autofluorescence spectrum. Methods: The concentration of protoporphyrin Ⅸ in 30 cases of colorectal cancer and 30 cases of normal people were detected, and the content of protoporphyrin Ⅸ in 60 cases of colorectal tissue (30 normal and 30 cases abnormal) was detected. Results: The blood protoporphyrin IX in cancer patients was significantly higher than that in normal people (P <0.05). The content of protoporphyrin IX in colorectal cancer tissues was higher than that in normal tissues (P <0.05). CONCLUSION: Abnormal increase of local porphyrin content in the intestine of the cancerous tissue is the material basis of the specific fluorescence peak at 644.3 ± 5.7 nm in the early stage of colorectal cancer diagnosed by autofluorescence.