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目的 :建立舒张性心力衰竭动物模型。方法 :应用心导管和超声心动图同步检查技术控制实验条件 ,通过缝扎冠状动脉造成心肌缺血使左室松弛、充盈功能减低、左室舒末压升高 ,而保持 L VEF≥ 4 5 %的实验状态。结果 :缺血即刻左室舒张末压从静息对照状态的 5 .3± 2 .8m m Hg( 1mm Hg=0 .13 3 k Pa)升高到 7.1± 2 .8m m Hg( P<0 .0 5 ) ,平均升高了 3 2 .4 %± 2 .8% ,左室松驰时间常数延长 ,左室舒张早期充盈速度减慢 ,L VEF从 5 7%± 6%减少到5 0 %± 8% ( P<0 .0 5 )。结论 :通过控制实验条件可建立舒张性心力衰竭的动物模型
Objective: To establish an animal model of diastolic heart failure. Methods: Synchronized cardiac catheterization and echocardiography were used to control the experimental conditions. Myocardial ischemia caused by left ventricular septal coronary artery stenosis, filling function decreased, left ventricular end-diastolic pressure increased, while maintaining L VEF ≥ 45% Experimental state. Results: Immediate left ventricular end-diastolic pressure increased from 5.3 ± 2.8 m m Hg (1 mm Hg = 0.133 kPa) to 7.1 ± 2.8 m m Hg (P <0 .05), with an average increase of 32.4% ± 2.8%. The left ventricular relaxation time constant was prolonged and the early left ventricular diastolic filling speed was slowed down. The L VEF decreased from 57 ± 6% to 50 % ± 8% (P <0.05). Conclusion: Animal models of diastolic heart failure can be established by controlling the experimental conditions