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目的:探讨飞行员单纯血肌酐（serum creatinine，Scr）升高时，以n 99mTc-二乙三胺五乙酸（diethylene triamine pentaacetic acid，DTPA）肾动态显像为标准方法测定肾小球滤过率（glomerular filtration rate，GFR）（以下简称n 99mTc-GFR）判断出现肾功能损害的情况；并比较血胱抑素C（cystatin C，Cys C）和GFR评估方程在单纯Scr升高的飞行人员中诊断的准确性。n 方法:以2018—2019年在中国民用航空局民用航空医学中心进行健康体检鉴定、2次Scr检测均增高的飞行员及飞行学员为研究对象。Scr取平均值，根据Scr值按照Cockcroft-Gault肌肝清除率（Cockcroft-Gault creatinine clearance，CG-CCr）评估方程和肾脏病膳食改良（modification of diet in renal disease，MDRD）公式计算出GFR（以下简称MDRD-GFR），并进行血Cys C、n 99mTc-GFR检查。按检查结果分为n 99mTc-GFR正常组（n 99mTc-GFR≥90 ml/min）和n 99mTc-GFR减低组（n 99mTc-GFR<90 ml/min）。n 结果:共入选95例，均为男性，平均年龄（35.27±10.32）岁。其中59例（62.1%）GFR减低。Scr、MDRD-GFR、Cys C、CG-CCr与总肾n 99mTc-GFR的相关性系数n r分别为0.218、0.535、0.808、0.857。在n 99mTc-GFR正常组和减低组间，MDRD-GFR、CG-CCr以及Cys C差异有统计学意义（n P<0.01）。n 结论:单纯Scr升高者中62.1%出现肾功能损害。除n 99mTc-GFR外，血Cys C以及CG-CCr诊断准确性较高，可以作为Scr升高者的补充检查。n “,”Objective:To evaluate the diagnosis of renal function impairment as the serum creatinine (Scr) level raised in pilots by determining the glomerular filtration rate (GFR) (n 99mTc-GFR) through diethylene triamine pentaacetic acid (DTPA) renal dynamic imaging standard method and to compare the accuracy of determining simply elevated Scr between the diagnosing of cystatin C (Cys C) and GFR evaluation for flying personnel.n Methods:In this study, pilots and pilot cadets whose Scr level was diagnosed raised twice in the physical examinations at Civil Aviation Medical Center of Civil Aviation Administration of China during 2018-2019 were selected as subjects. The GFR was calculated by the evaluation equations of Cockcroft-Gault creatinine clearance (CG-CCr) and the modification of diet in renal disease (MDRD-GFR) upon the averaged Scr level. Blood Cys C and n 99mTc-GFR were examined. According to the examination results, they were divided into n 99mTc-GFR normal group (n 99mTc-GFR≥90 ml/min) and n 99mTc-GFR reduced group (n 99mTc-GFR<90 ml/min).n Results:A total of 95 cases were enrolled, all male with an average age of (35.27±10.32) years. There were 59 cases with renal function impairment, accounting for 62.1%. The correlation coefficients n r of Scr, MDRD-GFR, Cys C, CG-CCr and total kidney n 99mTc-GFR were 0.218, 0.535, 0.808, 0.857, respectively. There were statistically significant differences in MDRD-GFR, CG-CCr and Cys C between normal and reduced n 99mTc-GFR groups (n P<0.01).n Conclusion:The percentage of renal impairment in simple Scr raised pilots is 62.1%. Besides n 99mTc-GFR, Cys C and CG-CCr have good diagnostic accuracy and can be used as a supplementary examination item for the patients with elevated Scr.n