论文部分内容阅读
前列腺素(Prostaslandins PGs)与消化性溃疡的发生及愈合之间的关系,逐渐受到学者们的关注,并不断有新的PGs类制剂应用于临床,从而为消化性溃疡的治疗开辟了新途径。本文将有关PGs抗溃疡机制及其临床应用现状综述如下: PGs抗溃疡机理 现已清楚,消化性溃疡患者的胃、十二指肠粘膜中内源性PGE含量明显低于正常人,而且这些患者在补充一定量的外源性PGs之后溃疡可见愈合。Wright等人发现:胃溃疡患者在病变活动期胃粘膜内PGE_2含量降低。周兰等人新近研究表明:十二指肠球部溃疡病变部位的PGE含量与正常相比减少,而在经用甲氰
The relationship between PGs and the occurrence and healing of peptic ulcer has gradually attracted the attention of scholars and new PGs have been continuously applied in the clinic, which opens a new way for the treatment of peptic ulcer. This article will PGs anti-ulcer mechanism and its clinical application of the situation are summarized as follows: PGs anti-ulcer mechanism is now clear, peptic ulcer patients, duodenal mucosa endogenous PGE levels were significantly lower than normal, and these patients Ulcer healing can be seen after a certain amount of exogenous PGs has been added. Wright et al found: gastric ulcer patients in the lesion activity of gastric mucosa decreased PGE_2 content. Zhou Lan, who recently showed that: duodenal ulcer lesion PGE content decreased compared with the normal, and in the use of cyanide