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目的 :探讨老年慢性心房颤动 (AF)患者脑缺血发生 (包括短暂性脑缺血发作及脑梗死或脑栓塞 )与血清脂蛋白 (a) [LP(a) ]浓度之间的关系。方法 :无脑缺血发生的慢性AF患者 70例 ,3个月以内曾出现脑缺血发作的慢性AF患者 6 2例 ,另选取有器质性心脑血管病但无AF的患者 6 4例作为对照组。采用酶联免疫吸附法(ELISA)测定LP(a)水平。结果 :脑缺血发生组LP(a)浓度显著高于无脑缺血发生组及对照组 (P <0 .0 5 ,P <0 .0 1) ,而无脑缺血发生组与对照组之间差异无统计学意义 (P >0 .0 5 )。结论 :老年慢性AF患者血清LP(a)浓度升高可能是导致脑缺血发作的原因之一。
Objective: To investigate the relationship between cerebral ischemia (including transient ischemic attack, cerebral infarction or cerebral embolism) and serum lipoprotein (a) [LP (a)] in elderly patients with chronic atrial fibrillation (AF). Methods: Seventy patients with chronic AF without cerebral ischemia, 62 patients with chronic AF who had cerebral ischemic attack within 3 months, and 64 patients with organic cardio-cerebrovascular disease without AF were enrolled in this study. As a control group. LP (a) levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: The LP (a) concentration in cerebral ischemia group was significantly higher than that in cerebral ischemic group and control group (P <0.05, P <0.01) The difference was not statistically significant (P> 0.05). Conclusion: Elevated serum LP (a) concentration may be one of the causes of cerebral ischemic attack in elderly patients with chronic AF.