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目的 研究巨细胞病毒 (CMV)肝炎患儿血清干扰素 α(IFN α)、白细胞介素 8(IL 8)和肿瘤坏死因子 α(TNF α)水平的变化及其临床意义。方法 应用ELISA法检测 35例CMV肝炎患儿血清中上述三种细胞因子的含量 ,并对其两两之间进行了相关性分析。结果 CMV肝炎组患儿IFN α、IL 8、TNF α的含量分别为 (770 .3± 2 0 5 .4 )ng/L、(41.9± 2 2 .5 )ng/L和 (10 33.2± 388.5 )ng/L ,非常显著高于正常对照组 (P <0 .0 1)。相关性研究发现IFN α与TNF α呈显著正相关 (r =0 .35 6 ,P <0 .0 5 )。结论 血清细胞因子明显增高与CMV肝炎的病理变化和病损程度有着密切的联系
Objective To investigate the changes of serum levels of interferon α (IFN α), interleukin 8 (IL 8) and tumor necrosis factor α (TNF α) in children with cytomegalovirus (CMV) hepatitis and their clinical significance. Methods Serum levels of the above three cytokines in 35 children with CMV hepatitis were detected by ELISA, and the correlation between them was analyzed. Results The levels of IFN α, IL 8 and TNF α in children with CMV hepatitis were (770.3 ± 20.5.4) ng / L, (41.9 ± 22.5) ng / L and (10 33.2 ± 388.5 ) ng / L, which was significantly higher than that of the normal control group (P <0.01). Correlation study found that IFNα and TNFα was significantly correlated (r = 0.356, P <0. 05). Conclusion Serum cytokines significantly increased with the pathological changes and lesions of CMV hepatitis are closely linked