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目的:制备异长春花碱脂质体,并考察其体外释放特性。方法:采用薄膜分散法制备异长春花碱脂质体,考察脂质体形态、粒径分布,透析法测定异长春花碱注射液和异长春花碱脂质体释药的差异。结果:异长春花碱脂质体平均粒径149.2 nm,透射电镜可以明显观察出脂质体的双分子层结构。异长春花碱脂质体和注射液的体外释放规律均符合Higuchi方程,脂质体在24 h内累积释放完而异长春花碱溶液在10 h内累积释放完全。结论:制备的VRB脂质体粒径均匀,外观良好,具有一定的缓释效果。
OBJECTIVE: To prepare isovanadine liposomes and investigate its in vitro release characteristics. Methods: The liposomes were prepared by thin-film dispersion method. The morphology and particle size distribution of the liposomes were investigated. The differences of the drug release between the both the vinblastine injection and the vinca liposomes were determined by dialysis. Results: The average particle size of V. vinca liposomes was 149.2 nm. The bilayer structure of the liposomes was clearly observed by transmission electron microscopy. The in vitro release patterns of both vinblastine liposomes and injections were in accordance with the Higuchi equation. The release of liposomes accumulated within 24 h and the vincristine solution released completely within 10 h. Conclusion: The prepared VRB liposomes have uniform particle size and good appearance with certain sustained release effect.