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目的 探讨食管鳞状细胞癌组织中多药耐药基因蛋白 (mdr 1)的表达及其对食管癌患者预后的影响。方法 应用免疫组织化学法 ,抗耐药基因蛋白单克隆抗体标记耐药基因蛋白。结果 多药耐药基因蛋白在食管鳞状细胞癌中的表达率为 32 .9% ,在正常组织中无表达 ;耐药基因蛋白的表达与肿瘤大小、侵袭深度及分化程度无明显相关 (P >0 .0 5 ) ,和癌症患者的术后生存时间呈明显负相关 (P<0 .0 1)。结论 食管鳞状细胞癌组织中耐药基因蛋白的表达可作为判断肿瘤患者预后不良的重要指标。
Objective To investigate the expression of multidrug resistance gene protein (mdr 1) in esophageal squamous cell carcinoma and its effect on the prognosis of patients with esophageal cancer. Methods Immunohistochemistry and anti-resistance gene protein monoclonal antibody were used to label drug resistance gene protein. Results The expression of multidrug resistance gene protein in esophageal squamous cell carcinoma was 32.9%, which was not expressed in normal tissues. The expression of multidrug resistance gene protein had no significant correlation with tumor size, invasion depth and differentiation degree (P > 0.05), and had a negative correlation with the postoperative survival time of cancer patients (P <0.01). Conclusion The expression of multidrug resistance protein in esophageal squamous cell carcinoma can be used as an important index to judge the prognosis of patients with cancer.