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本文根据亚硝酸钠在酸性条件下与芳香胺产生重氮化反应的原理,利用亚硝酸钠与甲氧普胺(Metoclo-pramide)产生电位差,采用自动电流滴定法对不同国家商品中的批量原料及制剂中的甲氧普胺进行了测定,并分别与英国药典(1980年版)的非水电位滴定法和片剂的分光光度法进行了比较,结果相仿。本法具有自动化、快速,简便、准确和重现性好等优点。在重氮化反应时,酸度在0.2M～0.9M,对一般原料药取样量可大至300mg;取样量为10mg 时,最佳酸度则为3.7M～4.7M。仪器采用自动微处理机滴定仪Mettler DL40 RC,双铂电圾(Mettelr DM142,140),组合铂环电极(Met-tler DM 140)。在使用双铂电极时,极化电流连接器应
Based on the principle of diazotization reaction of sodium nitrite with aromatic amines under acidic conditions, the potential difference between sodium nitrite and Metoclo-pramide was generated. The automatic current titration Metformin in raw materials and preparations was determined and compared with non-aqueous potentiometric titration and tablet spectrophotometry of the British Pharmacopoeia (1980 edition) respectively. The results were similar. This law has the advantages of automation, fast, simple, accurate and reproducible. In the diazotization reaction, the acidity of 0.2M ~ 0.9M, for the general bulk drug sample can be as large as 300mg; sampling volume of 10mg, the best acidity was 3.7M ~ 4.7M. The instrument uses an automatic microprocessor titrator Mettler DL40 RC, Mettler DM142,140, and Met-tler DM 140. When using a double platinum electrode, the polarization current connector should be