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临床研究表明,血管内皮生长因子(VEGF)在肺癌血管生长中起着重要作用。肿瘤生长、浸润和转移都依赖于肿瘤血管的生成,而持续表达的VEGF是肿瘤血管生成和肿瘤进展的关键介导因子,通过阻断VEGF信号来抑制血管新生是肿瘤治疗的重要措施之一。
Clinical studies have shown that vascular endothelial growth factor (VEGF) plays an important role in the angiogenesis of lung cancer. Tumor growth, invasion and metastasis all depend on tumor angiogenesis. Persistent expression of VEGF is a key mediator of tumor angiogenesis and tumor progression. Suppression of angiogenesis by blocking VEGF signaling is one of the important measures for tumor therapy.