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目的探讨胃肠间质瘤(GIST)的临床病理学特征。方法 26例胃肠间质瘤进行临床病理分析,讨论其临床病理特征。结果 26例GIST中21例位于胃,5例位于小肠。良性14例,恶性8例,未确定恶性潜能4例;梭形细胞型20例,上皮细胞型4例,混合细胞型2例。免疫组化:25例CD117(+),24例DOG1(+),19例CD34(+)。结论 GIST好发于中老年人,诊断主要依靠组织形态学特征和免疫组化,手术是重要和有效的治疗方法。
Objective To investigate the clinicopathological features of gastrointestinal stromal tumors (GIST). Methods Twenty - six cases of gastrointestinal stromal tumors were analyzed clinically and pathologically to discuss the clinicopathological features. Results In 26 cases of GIST, 21 cases were located in the stomach and 5 cases were located in the small intestine. Benign in 14 cases, malignant in 8 cases, unidentified malignant potential in 4 cases; spindle cell type in 20 cases, epithelial cell type in 4 cases and mixed cell type in 2 cases. Immunohistochemistry: 25 cases of CD117 (+), 24 cases of DOG1 (+), 19 cases of CD34 (+). Conclusion GIST occurs mainly in middle-aged and elderly people. The diagnosis mainly depends on histomorphological characteristics and immunohistochemistry. Surgery is an important and effective treatment.