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目的 了解发生在安徽省 2 0 0 2年 3例Ⅲ型脊髓灰质炎减毒活疫苗病毒衍生株 (VDPV)引起的病例的流行病学特征和临床表现。方法 病例个案调查。结果 3例分布在相距较远的农村地区 ,为 <2岁男孩 ,均发病于春夏季 ,有 2次或 3次脊髓灰质炎减毒活疫苗 (OPV)服苗史 ,其中 1例在服苗后 2 5d发病 ;病例有发热、非对称性麻痹、腱反射减弱、巴彬斯基征阴性和留有后遗症等临床表现 ,其中 2例临床症状严重。结论 首例Ⅲ型VDPV病例发生在安徽省 ,病例有增多的趋势 ;其流行学特征和临床表现与野病毒引起的病例相似 ;2例患儿因感染在环境中循环的Ⅲ型VDPV而发病 ;尚未发现该疾病的传播流行 ;OPV全程或未全程服苗的儿童均可发病
Objective To understand the epidemiological characteristics and clinical manifestations of 3 cases of VDPV (type 3) poliovirus-derived vaccine (VDPV) that occurred in Anhui Province in 2002. Methods Case investigation. Results Three cases were located in rural areas far away. They were all boys <2 years old, both of them were in spring and summer, with 2 or 3 times live attenuated polio vaccine (OPV) After 2 5d onset; case of fever, asymmetric paralysis, tendon reflexes decreased, Babinski sign negative and left sequelae and other clinical manifestations, of which 2 cases of severe clinical symptoms. Conclusions The first case of type Ⅲ VDPV occurred in Anhui Province. There was an increasing trend of cases. The epidemiological characteristics and clinical manifestations were similar to those caused by wild-type virus. Two cases were caused by infection with circulating type Ⅲ VDPV in the environment. Found that the spread of the disease epidemic; OPV whole or not the whole process of child-bearing children can be disease