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探讨药物总剂量(CD)、剂量强度(DI)、剂量密度对晚期卵巢上皮癌化疗的疗效。单纯延长化疗疗程数、提高化疗CD不会改善预后。同时增加顺铂DI和CD可能延长存活时间,尤其对残留小病灶者。紫杉醇及卡铂DI对预后影响不大。化疗间隔缩短1～2周称为剂量密度,一般称为周疗。紫杉醇周疗多用于二或三线化疗,疗效很好。顺铂周疗可用于残留小病灶的一及二、三线化疗。在保证最基本剂量基础上增加CD和DI或应用剂量密度化疗可能会改善预后。
To investigate the effect of total dose (CD), dose intensity (DI) and dose density on chemotherapy of advanced ovarian cancer. Simply extend the number of chemotherapy treatment, improve the chemotherapy CD will not improve the prognosis. Increased cisplatin DI and CD may prolong the survival time, especially for small residual lesions. Paclitaxel and carboplatin DI little effect on prognosis. Chemotherapy interval shortened 1 to 2 weeks called dose density, generally known as the week of treatment. Weekly paclitaxel for more than two or three lines of chemotherapy, the effect is very good. Cisplatin treatment can be used for residual small lesions of the first and second and third-line chemotherapy. Increasing CD and DI or applying dose-density chemotherapy based on the most basic dose may improve the prognosis.