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1病例资料患者,男,62岁,于1962年2月因严重肝硬化腹水,镜检大便发现大量密集的肝吸虫卵,诊断为肝吸虫病致肝硬化腹水。于1962年2月用氯喹啉治疗,每片0.25 g(含基质0.15 g),前30 d,2次/d,每次半片;后30 d,2次/d,1片/次,共服60 d,治疗结束后检查示大便虫卵未转阴[1]。该药疗程长、疗效差、不良反应大,曾引起溶血性黄疸致死1例[2],引起合并症致死2例[3]。随于1963年用硫酸二氯酚(日本产),50 mg/(kg·d),分3次口服,连服60 d,治疗结束后检查示大便虫卵未转阴。
1 Case data Patients, male, 62 years old, in February 1962 due to severe cirrhosis and ascites, microscopic examination of the stool found a large number of dense liver fluke eggs, diagnosis of hepatic cirrhosis ascites caused by ascites. In February 1962 with chloroquine treatment, each 0.25 g (containing substrate 0.15 g), the first 30 d, 2 times / d, each half a piece; after 30 d, 2 times / d, 1 / 60 d, after the treatment showed stool eggs did not turn negative [1]. The long course of treatment, poor efficacy, adverse reactions, has caused one case of hemolytic jaundice death [2], caused by complications of death in 2 cases [3]. With 1963 sulfuric acid dichlorophenol (Japan), 50 mg / (kg · d), 3 times orally, and even served 60 days after the treatment showed stool eggs did not turn negative.