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目的 探讨生存素在胃癌组织中的表达及其临床意义。 方法 应用免疫组织化学 SP法检测 1 0 5例胃癌组织中生存素的表达 ,分析生存素表达与临床病理学特征及预后的关系。 结果 胃癌组织中生存素表达的阳性率为4 7.6 %。生存素的表达与肿瘤浸润深度、淋巴结转移、TNM分期呈正相关性 (r分别为 :0 .2 83,0 .2 30和 0 .2 34,P<0 .0 5 ) ,与患者年龄、性别、肿瘤部位、Borrm ann分型及组织分化未见相关。生存素表达阳性者的 5年生存率 (30 .0 % )明显低于表达阴性者 (5 6 .4 % ,P=0 .0 0 7)。Cox回归模型显示 ,生存素表达与胃癌预后密切相关 (P<0 .0 5 ) ,是影响胃癌预后的独立因素。 结论 生存素在胃癌组织中高表达 ,且与肿瘤浸润深度、淋巴结转移及临床分期密切相关 ,是影响胃癌预后的重要分子指标
Objective To investigate the expression of survivin in gastric carcinoma and its clinical significance. Methods The expression of survivin in 105 cases of gastric carcinoma was detected by immunohistochemical SP method. The relationship between survivin expression and clinicopathological features and prognosis was analyzed. Results The positive rate of survivin expression in gastric carcinoma was 4 7.6%. The expression of survivin was positively correlated with the depth of tumor invasion, lymph node metastasis and TNM stage (r = 0.238, 0.230 and 0.234, respectively, P <0.05), but not with age, gender , Tumor site, Borrm ann classification and tissue differentiation no correlation. The 5-year survival rate (30.0%) of patients with positive survivin expression was significantly lower than those with negative expression (56.4%, P = 0.076). Cox regression model showed that survivin expression was closely related to the prognosis of gastric cancer (P <0.05), which was an independent factor affecting the prognosis of gastric cancer. Conclusions Survivin is highly expressed in gastric cancer tissues and closely related to the depth of invasion, lymph node metastasis and clinical stage, which is an important molecular indicator affecting the prognosis of gastric cancer