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1984年美国Currie和日本Kangawa实验室分别从5000只大鼠和40g人的心房组织中提取、分离、纯化出一类活性肽,称为心房肽(atripeptins)。心房肽的发现已经引起了全世界许多科学家的普遍重视和广泛兴趣。由于这种肽具有强烈的利尿、利钠作用,也称为心钠素(cardionatrin)和心房利钠多肽(atrial natrinretic polypeptide,ANP)。早在1964年,Jamieson和Palade曾发现,在心房组织中,含有一些能分泌蛋白或激素的颗粒。但长期以来,关于这种分泌颗粒的内容、特性及功能,并不了解。直至1979年DeBold才提出,这种颗粒可能与水、电解质平衡和细胞外液量的调节有关。他发现,禁水、忌钠的大鼠,心房内这种分泌颗粒明显增加;给试验大鼠静脉注射这种心房提取物,可有效地促进尿钠和尿量的排泄。以后,他们进一步发现,这种心房内的活性物质具有热稳定
In 1984, Currie and Kangawa Laboratories in Japan extracted, isolated and purified a class of active peptides called atripeptins from the atrial tissues of 5000 rats and 40 g of human respectively. The discovery of atrial natriuretic peptides has attracted the universal attention and widespread interest of many scientists around the world. Since this peptide has a strong diuretic, natriuretic effect, also known as cardionatrin and atrial natrinretic polypeptide (ANP). As early as 1964, Jamieson and Palade have found that in the atrial tissue contains some secreted protein or hormone particles. However, for a long time, the contents, characteristics and functions of this secreted granule are not known. It was not until DeBold proposed in 1979 that such particles may be related to the regulation of water, electrolyte balance and extracellular fluid volume. He found that forbidden to water, avoid sodium rats, the atrial secretion particles increased significantly; to the experimental rats intravenous injection of this atrial extract, can effectively promote urinary sodium and urine excretion. Later, they further found that the active substance in the atria is thermally stable