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免疫器官是免疫细胞再生、分化的重要场所,淋巴结(lymph nodes,LNs)作为外周免疫器官,其正常结构对于维持自身内环境稳定和免疫细胞的生存、发育、增生是非常重要的。近来,国外有研究发现胶原纤维在淋巴组织中T细胞区域(T cell zone,TZ)的沉积可能是导致HIV感染者外周血和淋巴组织中CD4~+T细胞减少的又一重要机制。该文拟根据近年研究进展,阐述LNs正常组织结构对CD4~+T细胞存活、发育和运输的影响及其结构改变与获得性免疫缺陷综合征(AIDS)发病机制的关系,以期对目前AIDS发病机制和临床治疗的研究有所裨益。
Immune organ is an important site for immune cell regeneration and differentiation. Lymph nodes (LNs) are the peripheral immune organs. Their normal structure is very important for the maintenance of their internal environment and the survival, development and proliferation of immune cells. Recently, foreign studies have found that the deposition of collagen fibers in T lymphocytes may be another important mechanism leading to the decrease of CD4 ~ + T cells in peripheral blood and lymphoid tissues of HIV-infected individuals. Based on the recent research progress, this paper elaborates the influence of LNs normal tissue structure on the survival, development and transport of CD4 ~ + T cells and the relationship between their structural changes and the pathogenesis of acquired immunodeficiency syndrome (AIDS) Mechanism and clinical treatment of the study of some benefit.