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22例使用庆大霉素的小儿患者,在监测血药浓度的同时,对尿中微球蛋白(β_2-MG)进行分析研究,结果在用药的第6天β_2—MG与用药前的有显著差异(p<0.05)。停药后的10—15天时间内,β_2—MG无显著变化(P>0.05)。说明监测β_2—MG与测定庆大霉素血药浓度在临床应用中同样重要。
In 22 pediatric patients with gentamicin, the urinary microglobulin (β_2-MG) was analyzed while monitoring plasma concentration. The results showed that β_2-MG on the 6th day was significantly higher than that before medication Difference (p <0.05). There was no significant change of β_2-MG within 10-15 days after drug withdrawal (P> 0.05). Description monitoring β_2-MG and determination of gentamicin plasma concentrations in clinical application is equally important.