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自从在寻常性天疮疱中免疫球蛋白G抗上皮抗体被发现后(Beutnerd1964:Beutner等1965),相似的抗体亦见之于烧伤的病人(Ablin等1969),药物疹(Chorzelshi等1966,Fellner等1970)和某些服用磺胺甲氧哒嗪而未曾发疹者,(Go,1969)。最近,在一例真性天疱疮病例,是否为由于应用D-青霉胺治疗而引起成了疑问(Hewitt etal,1971)由于这些发现指认由热或药物所致的上皮蛋白的变性,存在着产生抗上皮成分抗体产物的可能性,过去通过电子显微镜及萤光技术表明在斑丘疹性青霉素发疹的病人的
Similar antibodies have also been found in burned patients (Ablin et al., 1969), drug eruptions (Chorzelshi et al., 1966, Fellner et al., 1966), since immunoglobulin G anti-epithelial antibodies were found in common asterosclerosis (Beutnerd 1964: Beutner et al. Et al., 1970) and in some patients who did not have sulfamethoxypyrazide (Go, 1969). Recently, a case of TRB has been questioned for the treatment of D-penicillamine (Hewitt et al, 1971). Since these findings indicate the degeneration of epithelial proteins caused by heat or drugs, The possibility of anti-epithelial component antibody products, as evidenced by electron microscopy and fluorescence techniques in the past, has been shown in patients with rash of penicillin