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以高效液相色谱法测定血浆中的盐酸氟桂利嗪浓度。色谱条件：紫外检测波长２１０ｎｍ；柱ＳｐｈｅｒｉｓｏｒｂＣ８１５０×４．６ｍｍ；流动相：甲醇（８０％）∶水（１５％）∶（０．０５ｍｏｌ·Ｌ－１ＮＨ４Ｈ２ＰＯ４＋０．０２５ｍｏｌ·Ｌ－１Ｈ３ＰＯ４）缓冲液（５％）。最低检测限１０ｎｇ·ｍｌ－１。药物动力学为一室模型，其参数（Ｔ１／２（Ｋ）２．３８～２．６４ｈ，Ｔｍａｘ２．３０～２．４３ｈ，Ｃｍａｘ１３５．１３～１４３．９６ｎｇ·ｍｌ－１。
Determination of Flunarizine Hydrochloride in Plasma by High Performance Liquid Chromatography. Chromatographic conditions: UV detection wavelength 210nm; column Spherisorb C8150 4.6mm; mobile phase methanol (80%) water 15% 0.05mol·L -1 NH4H2PO4 0.025mol·L-1H3PO4 buffer (5% ). The minimum detection limit of 10ng · ml-1. Pharmacokinetic model for the one-compartment, the parameters (T1 / 2 (K) 2.38 ~ 2.64h, Tmax2.30 ~ 2.43h, Cmax135.13 ~ 143.96ng · ml-1.