论文部分内容阅读
由家兔耳静脉注入超生理阈值水平的去甲肾上腺素(NE)50ug/kg体重〔NE含于5ml生理盐水(NS)内,1ml/min〕,经10min后处死,取左室肌进行生化分析,结果显示环磷酸腺苷(cAMP)含量明显升高,表明心肌细胞膜的结构和功能遭受明显的损害,与对照组(只注射NS 5ml/5min)比较具有显著性统计学差异.我们采用镁制剂进行了实验研究,在输注NE前10min,经耳静脉注入硫酸镁200mg/kg体重(含于5mlNS内,1ml/min),结果显示NE的损害效应明显减轻,镁的拮抗能力在50%～80%幅度,与NE组比较,有显著性统计学差异,表明镁对心肌细胞膜结构和功能具有可靠的保护作用,对NE引起心肌细胞损害的毒性具有强力拮抗作用.
Rabbit ear vein injection of super-physiological threshold level of norepinephrine (NE) 50ug / kg body weight [NE contained in 5ml saline (NS), 1ml / min〕, after 10min was sacrificed and left ventricular muscle biochemical Analysis showed that the content of cAMP increased significantly, indicating that the structure and function of myocardial cell membrane suffered significant damage compared with the control group (NS only injection 5ml / 5min) compared with significant statistical differences.We use magnesium 10 min before infusion of NE, 200 mg / kg body weight of magnesium sulfate (contained in 5 ml NS, 1 ml / min) was injected via the ear vein. The results showed that the damage effect of NE was significantly reduced and the antagonistic ability of magnesium was 50% ~ 80% amplitude, compared with NE group, there is a significant statistical difference, indicating that magnesium myocardial cell membrane structure and function of a reliable protective effect of NE-induced cardiomyocyte damage toxicity has a strong antagonistic effect.