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白血病患儿对感染的抵抗力降低,有很大危险;口腔粘膜损害往往成为感染侵入的门户。作者检查171例急性白血病小儿,年龄1～15岁,口腔损害率很高,39.7%有感染;口腔粘膜坏死,念珠菌病,急性疱疹性口炎,有的合并坏死性咽炎和食管炎。38%有口腔营养障碍:红唇缘干燥,舌丝状乳头脱屑,形成营养性溃疡等。19%有出血症状:瘀血斑疹、血肿、从口腔粘膜取坏死性苔膜时出血或自发性出血。大多数患儿唾液免疫球蛋白含量降低,特别是IgA,这表明口腔损害除全身原因外,和局部免疫缺陷有关。治疗白血病患儿的口腔损害,作者采用综合疗法,除提高全身免疫力以外,局部补
Children with leukemia reduce the resistance to infection, there is a great danger; oral mucosal damage often become the gateway to infection invasion. The authors examined 171 children with acute leukemia aged 1 to 15 years with high rates of oral damage and 39.7% of infections; oral mucosal necrosis, candidiasis, acute herpetic stomatitis, and some with necrotizing pharyngitis and esophagitis. 38% have oral dystrophy: red lips dry, tongue filiform nipple scaling, the formation of nutritional ulcers and so on. 19% had bleeding symptoms: blood stasis rash, hematoma, necrotizing lichen planus from the oral mucosa hemorrhage or spontaneous bleeding. Most children have reduced salivary immunoglobulin levels, especially IgA, indicating that oral damage is associated with local immunodeficiency, in addition to systemic causes. Treatment of oral dysfunction in children with leukemia, the authors use a combination therapy, in addition to improving systemic immunity, local complement