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目的通过对日军鼠疫细菌战幸存者流行病学资料调查和F1抗体检测分析,为浙江省丽水市历史上鼠疫暴发是日军细菌战所引发提供生物学证据。方法通过浙西南“侵华日军细菌战”档案抢救与保护中心寻访到丽水市36名鼠疫细菌战受害幸存者,采用回顾性个案调查的方法进行流行病学调查,并采集静脉血标本进行鼠疫F1抗体检测。结果时隔70年,仍能从当年国民政府诊断为鼠疫患者的25%的幸存者中检测到高滴度F1抗体。结论日军细菌战制造了一个严重的细菌污染区,留下长期隐患,给丽水市当地居民带来了巨大的伤害。
OBJECTIVE: To investigate the epidemiological data of the plague survivors and the detection of F1 antibody in Japanese plagues to provide biological evidence for the plague outbreak in the history of Lishui City, Zhejiang Province. Methods To investigate the epidemic of 36 plague plague survivors in Lishui city through the rescue and protection center of file “Germ warfare against Japanese aggression in China” in southwestern Zhejiang Province. The epidemiological investigation was conducted by means of retrospective case investigation and the venous blood samples were collected Plague F1 antibody test. Results After seventy years, high-titer F1 antibodies were still detected in 25% of survivors diagnosed as plague patients by the National Government of that year. Conclusion The Japanese Bacteriological Warfare has created a serious bacterial contamination area, leaving long-term hidden dangers to the local residents in Lishui City.