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在过去5年,淋球菌对抗生素的耐药性已迅速增加.由于产生青霉素酶的奈瑟氏淋球菌高度流行,自1981年注意观察用大观霉素治疗淋球菌感染.但失败的病例报告日益增多.为确定大观霉素治疗淋球菌感染的效果,对一组患尿道淋球菌感染的患者进行了研究.有97人接受了大观霉素治疗,并进行随访.结果有8(8.2%)人治疗失败.从7名治疗失败者的分离菌株的药敏试验表明,有6株对大观霉素耐药,最小抑菌浓度≥100μg/ml.但无一株对青霉素耐药,淋球菌对头孢西丁、头孢三嗪和氟嗪酸普遍敏感.对大观
Neisseria gonorrhoeae has rapidly increased its resistance to antibiotics over the past five years, and due to the high prevalence of Neisseria gonorrhoeae producing penicillin, attention has been given to the observation of N. gonorrhoeae infection with spectinomycin since 1981. However, reports of failed cases are increasingly reported In an effort to determine the efficacy of spectinomycin in the treatment of gonococcal infections, a group of patients with gonococcal urinary tract infections were studied, 97 of whom received spectinomycin and were followed up with a mean of 8 (8.2%) Treatment failed .From the seven susceptible strains of drug-susceptibility tests showed that there are 6 strains of spectinomycin resistance, the minimum inhibitory concentration ≥ 100μg / ml. But none of penicillin-resistant, Neisseria gonorrhoeae against cephalosporins Xidin, ceftriaxone and triflusal are generally sensitive