论文部分内容阅读
目的比较注意缺陷多动障碍(ADHD)儿童服用哌甲酯治疗前后其探究性眼球运动(EEM)的变化。方法收集ADHD患儿32例(病例组),男23例,女94例;年龄(10.25±2.08)岁,口服哌甲酯后进行EEM检测;30例健康儿童作为对照组;比较二组儿童眼球注视点数目(NEF)、反应性探究评分(RSS)的差异。应用SPSS 13.0软件进行统计学分析。结果 ADHD患儿服药后其NEF[(26.59±3.83)个]、RSS[(5.97±1.59)分]较服药前NEF[(23.77±5.29)个]、RSS[(5.03±1.80)分]增高,差异具有统计学意义(Pa<0.05),但服药后较健康对照组NEF[(28.40±2.58)个]、RSS[(7.83±1.91)分]降低,二者比较差异有统计学意义(P<0.05,0.01)。结论哌甲酯可能会改善ADHD儿童额叶-纹状体环路的注意性和抑制性执行功能。
Objective To compare the changes of exploratory eye movement (EEM) in children with attention deficit hyperactivity disorder (ADHD) before and after taking methylphenidate. Methods Thirty-two ADHD children (23 cases) were enrolled in this study. EME was detected after oral administration of methylphenidate in aged (10.25 ± 2.08) years. Thirty healthy children served as the control group. Differences in NEF, Reactive Exploratory Score (RSS). SPSS 13.0 software was used for statistical analysis. Results Compared with pretreatment NEF [(26.59 ± 3.83)] and RSS [(5.97 ± 1.59)], NEF [(23.77 ± 5.29)] and RSS [(5.03 ± 1.80) (P <0.05). However, compared with healthy control group, NEF [(28.40 ± 2.58)] and RSS [(7.83 ± 1.91) min] decreased after treatment compared with the control group (P < 0.05, 0.01). Conclusion Methylphenidate may improve the attentive and inhibitory executive function of the frontal lobe-striatal loop in children with ADHD.