Facile synthesis and cytotoxicity of 5-C-alkylates of 20(S) camptothecins

• 作 者: Di Zao Li Xian Dao Pan Hong Ya
• 机 构: Institute of Materia Medica
• 出 处: 中国化学快报（英文版）
• 发表日期: 2004年期
• 关键词: Camptothecin Synthesis 5-C-Alkylate Antitumor aetivity

A series of 5-C-alkylating camptothecins have been synthesized by one-step method.and their in vitro antitumor activity was evaluated against six human cancer cell lines.The results showed that all 5-C-alkylatcs of camptothecins possessed poor cytotoxicity on six human cancer cell lines.