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心房肌细胞贮有高浓度的强烈利钠作用的肽类物质——心房利钠肽(atrial natriuretic peptide,A-NP),细胞外液容量变化引起心房扩张,刺激其释放入循环而发挥利钠激素的作用。研究对象 11例急性充血性心衰病人,年龄39～84(平均69)岁,均符合下列标准:①有呼吸困难及端坐呼吸的病史;②颈静脉压力升高及肺水肿的临床表现;③左心衰竭的放射学证据。需要机械通气及常规疗法不能控制心衰及瓣膜心脏病人除外。入院前未用利尿剂,其它治疗不变。入院当天8例用速尿40～120mg,其余3例分别用安体舒通与双氢氟噻嗪复
Atrial natriuretic peptide (atrial natriuretic peptide, A-NP), atrial natriuretic peptide (A-NP), stores a high concentration of atrial natriuretic peptide (Atrial natriuretic peptide) in the atrial myocytes and changes in the extracellular fluid volume cause atrial expansion and stimulates the release of sodium into the circulation The role of hormones. Subjects: Eleven patients with acute congestive heart failure, aged from 39 to 84 (mean, 69), all met the following criteria: (1) a history of dyspnea and sitting breathing; (2) clinical manifestations of jugular venous hypertension and pulmonary edema; ③ left ventricular failure of radiological evidence. Need mechanical ventilation and conventional therapy can not control heart failure and valvular heart disease except. Unused diuretics before admission, other treatment unchanged. 8 cases on admission day with furosemide 40 ~ 120mg, and the remaining 3 cases were spironolactone and dihydrofluidiazide complex