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家蚕微孢子虫研究在近10年取得了突飞猛进的发展,特别是其基因组学分析和侵染相关分子的研究不断推进,为深入开展家蚕微孢子虫功能基因组学研究奠定了基础.通过蛋白质组与功能基因组研究平台,对家蚕微孢子虫孢壁蛋白和分泌蛋白的鉴定以及在微孢子虫侵染中的生物学功能展开了系统的研究;同时,从分子生物学水平详尽研究了家蚕微孢子虫侵染相关分子机制,从蚕业生产实践着手构建家蚕微孢子虫检测防控技术体系,利用现代分子生物学技术探索针对家蚕微孢子虫的家蚕抗性种质材料创建.可以预期,在近10年的研究基础上,未来对家蚕微孢子虫的研究将在侵染与垂直传播机制、分子检测、抗性素材分子育种等方面取得重大突破,并为其它微孢子虫的研究提供信息支持.“,”In the past decade,researches in Nosema bombycis have advanced rapidly.Especially,great progress in genomics analysis and invasion mechanisms have laid a solid foundation for further study on functional genomics of N.bombycis.Comprehensive studies have been carried out by researchers to identify spore wall proteins and secreted proteins and to discover their biological functions in infection process via the research platforms of proteomics and functional genomics.Nevertheless,researchers also conducted in-depth studies on the invasion mechanism of N.bombycis at molecular level,constructed detection and control system against this pathogen for sericultural production,and explored innovation measures for resistant silkworm germ resources through modern molecular biological technology.It is anticipated that,based on the research achievements in recent ten years,significant breakthroughs will be made on studying invasion mechanism,vertical transmission,molecular detection,and breeding of resistant silkworm lines against N.bombycis in the future,all of which would provide good references for researches on other microsporidian species.