Implications of the mismatch repair-deficient status for the management of colorectal cancers

• 作 者: Qing Wei Lin Shen
• 机 构: DepartmentofGastrointestinalOncology
• 出 处: Oncology and Translational Medicine
• 发表日期: 2017年1期
• 关键词: colorectal cancer (CRC) MISMATCH repair MICROSATELLITE INSTABILITY IMMUNOTHERAPY

Although the majority of colorectal cancer(CRC)cases develop through the CIN pathway,approximately15%of cases are caused by the hypermutation known as microsatellite instability(MSI)that is a consequence ofdeficient(d)DNA mismatch repair(MMR).dMMR CRCs ha