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目的 探讨瘦素与雌激素在子宫肌瘤发病中的意义。方法 对 5 3例子宫肌瘤患者子宫全切术前(卵泡期 )测定血清瘦素 (leptin)、促卵泡素 (FSH)、促黄体生成素 (LH)、雌二醇 (E2 )、睾酮 (T)水平 ,并与正常对照组雌激素水平进行比较。对病例组中的雌激素、睾酮与瘦素水平进行相关性分析。结果 子宫肌瘤患者的血清雌二醇水平与对照组无显著性差异 (Dt=- 0 .0 1 2 ,P =0 .91 2 )。子宫肌瘤患者的血清雌二醇水平与瘦素水平呈正相关(r =0 .2 1 6 ,P =0 .346 ) ;睾酮与瘦素水平也呈正相关 (r=0 .0 76 ,P =0 .74 3)。结论 瘦素与子宫肌瘤的发生、发展有关。
Objective To investigate the significance of leptin and estrogen in the pathogenesis of uterine fibroids. Methods Serum levels of leptin, follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and testosterone (T) were measured before hysterectomy (follicular phase) Level, and compared with normal control group estrogen levels. The correlation between estrogen, testosterone and leptin in case group was analyzed. Results The serum estradiol level of uterine fibroids patients was not significantly different from that of the control group (Dt = - 0.122, P = 0.91 2). Serum estradiol level in patients with uterine fibroids was positively correlated with leptin level (r = 0.26, P = 0.346); testosterone was also positively correlated with leptin level (r = 0.76, P = 0 .74 3). Conclusion Leptin and uterine fibroids on the occurrence and development.