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利福平(RFP)是目前杀菌作用最强的抗麻风药,已广泛用于麻风的治疗,但对其副作用尚欠充分报导,麻风联合化疗会议上也很少讨论。用RFP的药物反应与投药的间隔时间有关。Giyling等强调,几乎所有关于RFP药物反应的资料都是从结核病人中获得的。自麻风用RFP以来,也报导过一些有药物反应的病例。皮肤反应——Giyling等报导每日或间隔服RFP,有5％的病人可出现面颈部潮红,伴发痒或全身发疹,但皮疹轻而为时短暂。若皮疹持久不退则需脱敏。脱敏可从75mg开始,在一周内递增至常量。陈氏报告1例
Rifampicin (RFP), the anti-leprosy drug with the strongest bactericidal effect, has been widely used in the treatment of leprosy, but its side effects have not yet been fully reported and rarely discussed at leprosy combined with chemotherapy. Drug reactions with RFP are related to the interval between administrations. Giyling et al emphasize that almost all the information on the response to RFP drugs is obtained from TB patients. Since the leprosy with RFP, there have also been reports of some cases of drug reactions. Skin reaction - Giyling et al reported daily or intermittent service RFP, 5% of patients may have face and neck flushing, itching or systemic rash, but the rash and transient short-lived. If the rash persistent without desensitization. Desensitization starts at 75 mg and increments to a constant within a week. Chen reported 1 case