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目的 :探讨造血干细胞移植后 7例白血病患者骨髓重建的血象变化规律。方法 :常规采髓 ,应用百特CS - 3 0 0分离外周血干细胞 ,动态观察移植后血象、骨髓象。结果 :① 移植后 1～ 2周骨髓呈极度抑制 ,第 3周出现恢复征象 ,5～ 6周骨髓造血恢复正常。② 红系中最先出现中、晚幼红细胞 ,粒系以原始、早幼粒先出现 ,巨核系统恢复最慢。③ 平均血小板体积 (MPV)在预处理后明显下降 ,随着造血功能恢复而逐步回升 ,早幼粒细胞数、血小板数回升。结论 :① 预处理后预防出血措施应持续至 5～ 6周 ;②MPV变化与骨髓造血功能有关 ,可做为观察造血干细胞植入和骨髓造血重建的指标。
Objective : To investigate the blood changes of bone marrow reconstitution in 7 leukemia patients after hematopoietic stem cell transplantation. METHODS: Conventional medullary cannulae were used to isolate peripheral blood stem cells using Baxter CS-300, and the blood and bone marrow images were observed dynamically after transplantation. RESULTS: 1 The bone marrow was extremely inhibited 1 to 2 weeks after transplantation. The signs of recovery appeared in the 3rd week, and the bone marrow hematopoiesis returned to normal after 5 to 6 weeks. 2 Erythroblasts were the first to appear in middle and late erythrocytes. The granules first appeared in primitive, early seedlings, and the megakaryocyte system recovered the slowest. 3 Mean platelet volume (MPV) decreased significantly after pretreatment, gradually recovered with hematopoietic recovery, and the number of promyelocytes and platelets increased. Conclusion :1 Preventive hemorrhage after pretreatment should last for 5-6 weeks; 2MPV changes are related to bone marrow hematopoietic function and can be used as indicators for hematopoietic stem cell implantation and bone marrow hematopoietic reconstruction.