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【目的】探讨二藤通痹合剂配合康复体操疗法在强直性脊柱炎(ankylosing spondylitis,AS)治疗中的临床疗效。【方法】将82例AS患者随机分为治疗组和对照组各41例。2组患者均给予二藤通痹合剂(主要由南蛇藤和鸡血藤两味药组成)口服,治疗组在此基础上配合康复体操疗法,采用视觉模拟评分法(VAS)及AS疗效评价标准20反应方案(ASAS 20)进行评估,并做比较分析。【结果】(1)治疗12周后,治疗组疗效显著优于对照组,2组比较差异有统计学意义(P<0.05)。(2)治疗后,治疗组和对照组脊柱痛、外周关节疼痛及肿胀数、晨僵时间、患者躯体功能(BASFI)等均显著改善,与治疗前比较差异均有统计学意义(P<0.05),且治疗组的改善作用均优于对照组(P<0.05)。(3)治疗期间,2组的血常规和肝、肾功能等实验室检测指标均无明显改变,具有较好的安全性。【结论】二藤通痹合剂配合康复体操治疗强直性脊柱炎疗效确切,且安全性好。
【Objective】 To investigate the clinical efficacy of Er Teng Tong Bi Mixture in combination with rehabilitation gymnastics in the treatment of ankylosing spondylitis (AS). 【Methods】 82 AS patients were randomly divided into treatment group and control group, 41 cases each. Two groups of patients were given two Totongbi mixture (mainly composed of Celastrus and Jixue two herbs) oral treatment group based on the rehabilitation gymnastics therapy with visual analogue scale (VAS) and AS evaluation criteria 20 Response Protocol (ASAS 20) were evaluated and compared for analysis. 【Results】 (1) After 12 weeks of treatment, the treatment group was significantly better than the control group, the difference was statistically significant (P <0.05). (2) After treatment, pain and swelling of peripheral joints, morning stiffness and body function (BASFI) of the treatment group and the control group were significantly improved (P <0.05, P <0.05) ), And the treatment group improved better than the control group (P <0.05). (3) During the treatment period, there was no obvious change in the blood test, liver function test and laboratory test in the two groups, which showed good safety. 【Conclusion】 Er Teng Tong Bi Mixture with rehabilitation gymnastics treatment of ankylosing spondylitis is effective and safe.