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瘙痒是慢性胆汁郁积特别是原发性胆汁性肝硬变(PBC)患者的一种痛苦症状,其治疗有消胆胺、苯巴比妥、雄激素类、去血浆法、光疗、组胺拮抗剂和维生素 P 类。近年观察表明对肝脏微粒体功能有增强作用的抗生素利福平也能减轻 PBC 的瘙痒。本文作者比较了利福平和苯巴比妥对 PBC 患者的止痒疗效。方法选22例女性患者,平均年龄49.7岁,临床、生化、免疫及组织学均具有 PBC 特征。两药各用14天,其中间隔30天,服药先后次序随机安排,利福平剂量为10mg/kg,苯巴比妥为3mg/kg。服药开始和结束时均用标准方法测定血清胆红素、丙氨酸转氨
Pruritus is a painful condition in patients with chronic cholestasis, especially in patients with primary biliary cirrhosis (PBC) treated with cholestyramine, phenobarbital, androgens, plasmapheresis, phototherapy, histamine antagonism Agents and vitamin P class. In recent years, observation shows that the role of the liver microsomal function of the antibiotic rifampicin can also reduce the pruritus of PBC. The authors compared the effects of rifampin and phenobarbital on itch in PBC patients. Methods Twenty-two female patients were selected, with an average age of 49.7 years. Clinical, biochemical, immunological and histological features were all PBC. The two drugs each with 14 days, of which 30 days interval, taking the order of treatment were randomized, rifampicin dose of 10mg / kg, phenobarbital 3mg / kg. Serum bilirubin and alanine transaminase were determined by standard methods at the beginning and at the end of medication