Drug release from a coated planar matrix with a super- saturation loading in the core (Ⅱ) ——In vitro

• 作 者: 徐铜文 何炳林
• 机 构: Department of Applied Chemistry, University of Science and Teehnology of China, Hefei 230026, China,
• 出 处: Progress in Natural Science
• 发表日期: 2000年11期
• 关键词: saturation coated methacrylate copolymer hydroxyethyl alcohol vinyl polymeric ac

The preparation and characterization of 5-fluorouracil/ethylene-vinyl alcohol copolymer (5-Fu/E-VAL) matrix coated with various polymeric materials are reported. The coating materials studied here include ethylene-vinyl alcohol copolymer (EVAL) , cellulose acetate (CA) , poly-2-hydroxyethyl methacrylate (PHEMA) and poly-methyl methacrylate (PMMA) with different diffusivities and thicknesses. To validate the proposed model equations, these coated systems were investigated experimentally and quantitatively. The results show a good correlation between theoretical predictions and experimental data.

The preparation and characterization of 5-fluorouracil / ethylene-vinyl alcohol copolymer (5-Fu / E-VAL) matrix coated with various polymeric materials are reported. The coating materials studied here include ethylene-vinyl alcohol copolymer (EVAL) CA), poly-2-hydroxyethyl methacrylate (PHEMA) and poly-methyl methacrylate (PMMA) with different diffusivities and thicknesses. The results show a good correlation between theoretical predictions and experimental data.