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目的观察沙丁胺醇联合布地奈德雾化吸入治疗急性支气管哮喘的临床疗效。方法将100例符合纳入标准的急性支气管哮喘患者,按照就诊先后顺序,用随机数字表法(1∶1)分为两组,每组50例。对照组给予抗炎、吸氧、吸痰、镇静、维持水电解质平衡、纠正酸碱紊乱、补液等治疗,并加用0.5%沙丁胺醇雾化液0.25 ml加入生理盐水2 ml中,用PARI雾化泵雾化吸入,5～10 min/次2,～4次/d;治疗组在对照组治疗基础上加用布地奈德混悬液0.5～1 mg加入生理盐水与沙丁胺醇混合液2 ml中,用PARI雾化泵雾化吸入,5～10 min/次,2～4次/d。两组均以7 d为1个疗程。结果①两组疗效比较:对照组平均秩次为43.94,治疗组为57.06。Mann-Whitney U统计量为922.00,Wilcoxon W为2197.00,Z检验统计量为Z=-2.438,P=0.015(双侧),两组疗效比较差异有统计学意义,治疗组优于对照组。②总有效率治疗组为88.00%,对照组为72.00%,两组比较差异有统计学意义(χ2=4.000,ν=1,P=0.046),,治疗组优于对照组。③两组均按时完成了治疗,未发现治疗有明显的毒副作用和不良反应,显示了治疗药物良好的依从性。结论沙丁胺醇联合布地奈德雾化吸入治疗急性支气管哮喘有较好的临床疗效,且副作用小,依从性好,值得进一步研究。
Objective To observe the clinical efficacy of salbutamol combined with budesonide inhalation in the treatment of acute bronchial asthma. Methods A total of 100 patients with acute bronchial asthma who met the inclusion criteria were divided into two groups (n = 50) with random number table (1: 1). The control group was given anti-inflammatory, oxygen, sputum, sedative, to maintain the balance of water and electrolyte, to correct acid-base disorders, rehydration and other treatments, and add 0.5% salbutamol nebulizer 0.25 ml saline 2 ml, PARI atomization Pump inhalation, 5 ~ 10 min / times 2, ~ 4 times / d; the treatment group in the control group based on the treatment with budesonide suspension 0.5 ~ 1 mg was added saline and salbutamol mixture 2 ml, PARI atomization pump atomized inhalation, 5 ~ 10 min / time, 2 ~ 4 times / d. Both groups were 7 days for a course of treatment. Results ① Comparison of the two groups: the average rank of the control group was 43.94, and the treatment group was 57.06. Mann-Whitney U statistic was 922.00, Wilcoxon W was 2197.00, Z test statistic was Z = -2.438, P = 0.015 (both sides), the difference between the two groups was statistically significant, the treatment group was better than the control group. ② The total effective rate was 88.00% in the treatment group and 72.00% in the control group. There was significant difference between the two groups (χ2 = 4.000, ν = 1, P = 0.046). The treatment group was superior to the control group. ③ Both groups completed the treatment on time and did not find the treatment has obvious side effects and adverse reactions, showing the good compliance of the treatment drug. Conclusions Salbutamol combined with budesonide inhalation is effective in the treatment of acute bronchial asthma with small side effects and good compliance, which deserves further study.