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南京药学院、镇江市第二人民医院、江苏省“五七”干校制药厂(镇江地区制药厂)共同研制的治疗肝炎药物水飞蓟宾于去年12月1～3日,由江苏省科委、省卫生厅组织鉴定。 1977年,南京药学院从菊科水飞蓟属水飞蓟果实中提得水飞蓟宾。1978年,三个单位开始共同进行水飞蓟宾的水溶性衍生物及其制剂的研究工作,试制出水飞蓟宾葡甲胺盐(silybin-N-methylglucamine)片剂,每片含药50mg,100mg;水飞蓟宾邻苯二甲酸单酯钠(silybin phthalic acid monoester sodium salt)针剂,每支含25mg,50mg。其药理、毒理试验结果与国外文献报道一致,有保护及稳定肝细胞膜的作用。1979年7月试用于临床,经11个临床单位256例临床试用结果表明,对慢性肝炎总有效率达74.6%,显效率52.0%。其中慢性迁延性肝炎201例,总有效率73.1%,显效率53.0%;慢性活动性肝炎55例,总有效率80%,显效率47.3%。均未见毒
Drugs for the treatment of hepatitis, jointly developed by Nanjing Pharmaceutical University, Zhenjiang Second People’s Hospital, and the “7-7” dry school pharmaceutical factory in Jiangsu Province (Zhejiang Regional Pharmaceutical Factory), were published on December 1–3 last year by Jiangsu Province. The Science and Technology Committee and the Provincial Health Department organize the appraisal. In 1977, Nanjing College of Pharmacy raised silibinin from the fruit of thistle plant Silybum rubrum. In 1978, the three companies began to jointly conduct research on the water-soluble derivatives and preparations of silybin, and made trials of silybin-N-methylglucamine tablets, each containing 50 mg of the drug. 100 mg; silybin phthalic acid monoester sodium salt injection, each containing 25 mg, 50 mg. The results of its pharmacological and toxicological tests are consistent with those reported in foreign countries and have the effect of protecting and stabilizing hepatic cell membranes. In July 1979, it was tested in clinical practice. The results of 256 clinical trials in 11 clinical units showed that the total effective rate for chronic hepatitis was 74.6% and the markedly effective rate was 52.0%. Of these, 201 cases of chronic persistent hepatitis, the total effective rate of 73.1%, significant efficiency of 53.0%; chronic active hepatitis in 55 cases, the total effective rate of 80%, significant efficiency of 47.3%. No poison