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目的:观察帕罗西汀联合心理干预治疗多发性硬化伴抑郁的疗效。方法:42例多发性硬化伴抑郁患者随机分为联合治疗组22例,帕罗西汀治疗组20例;于治疗前、治疗后6周进行汉密顿抑郁量表(HAMD)及日常生活活动能力(ADL)量表测定。结果:与治疗前相比,两组在治疗后HAMD、ADL评分均有显著差异(P<0.01);治疗后两组间各项评分亦有显著性差异(P<0.05)。结论:帕罗西汀联合心理干预能明显减轻多发性硬化所致的抑郁状态,疗效优于单用抗抑郁药物帕罗西汀。
Objective: To observe the curative effect of paroxetine combined with psychological intervention on multiple sclerosis with depression. Methods: Forty-two patients with multiple sclerosis and depression were randomly divided into combined therapy group (n = 22) and paroxetine treatment group (n = 20). HAMD and activities of daily living before treatment and 6 weeks after treatment ADL) scale determination. Results: Compared with those before treatment, the scores of HAMD and ADL in both groups were significantly different after treatment (P <0.01). There was also significant difference between the two groups after treatment (P <0.05). Conclusion: Paroxetine combined with psychological intervention can significantly reduce the depression caused by multiple sclerosis, the effect is superior to single anti-depressant paroxetine.