【摘 要】
：
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide.In the last few
【机 构】
：
State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shan
论文部分内容阅读
Hepatocellular carcinoma (HCC) is currently the fifth most common malignancy and the third leading cause of cancer-related mortalities worldwide.In the last few years,treatments for HCC have significantly improved from a mere surgical resection to a series of minimally invasive therapies and targeted drugs.However,recurrence frequently occurs even upon curative therapeutics,and drug therapies generally produce disappointing results,with the overall prognosis dismal.This challenging clinical scenario warrants new effective and life-prolonging strategies for patients with HCC.Compemng evidence suggests that NK cells play a critical role in the immune function of the liver and in the immune defenses against HCC,indicating that HCC might be an ideal target for NK cell-based immunotherapies.To obtain comprehensive insights into the putative influence of NK cells on HCC,this paper summarizes current knowledge on NK cells in HCC and discusses the usefulness and prospects of NK cell-based immunotherapies.Critical issues that require consideration for the successful clinical translation of NK cell-based therapies are also addressed.If appropriately used and further optimized,NK cell-based therapies could dominate important roles in the future immunotherapeutic market of HCC.
其他文献
Natural killer (NK) cells are considered to be critical players in anticancer immunity.However,cancers are able to develop mechanisms to escape NK cell attack o
Umbilical cord mesenchymal stem cells (MSCs) are a unique,accessible,and non-controversial source of early stem cells that can be readily manipulated.As the mos
T cells are an important adaptive immune response arm that mediates cell-mediated immunity.T cell metabolism plays a central role in T cell activation,prolifera
Pueraria mirifica Airy Shaw et Suvatabandhu is a medicinal plant endemic to Thailand.It has been used in Thai folklore medicine for its rejuvenating qualities i
MicroRNAs (miRNAs) play critical roles in the development and progression in various cancers.Dysfunctional miR-9 expression remains ambiguous,and no consensus o
水稻种子质量是决定水稻产量的重要因素,直接关系到粮食生产的安全。获得高活力种子是判断最佳收获期的前提,对提高种子质量非常重要。不同成熟度对种子活力影响很大,种子活力是在种子发育过程中形成的。而在作物种子贮藏过程中种子老化现象也普遍存在。对于贮藏过长等原因而导致活力下降的种子,可利用引发技术部分恢复其活力。本文以杂交水稻株两优06(籼稻)和春优84(粳稻)种子为材料,开展了杂交水稻种子最佳收获期、不
在上海郊区首次应用微气象学方法测定了尿素施于栽培甘蓝田间后的氨挥发损失。尿素用量225公斤/公顷。尿素分100%表施与尿素70%混施于土层(另30%表施)两处理。连续11天累计的
芒属于小麦穗部重要的光合器官,与其他光合器官相比,芒具有许多有利于光合作用的条件。研究发现芒和叶片具有同样的光合功能和相同的碳同化途径,特别在旗叶衰老的后期,芒仍具有较高的光合活性。此外芒还在抵抗虫害,防止脱粒方面也有着非常重要的作用。自20世纪初,小麦育种工作者就已经开展了对小麦芒性的生理、作用和遗传特性的研究。本研究以一对芒长度存在差异的近等基因系SN051-1(长芒)与SN051-2(短芒)
艺德是艺术行业工作者的一种职业道德,作为培养艺术类研究生的艺术院校,如何应时代要求和学校以及学生自身特点塑造并形成这一道德品质与行为准则,这是值得我们深思的问题。