论文部分内容阅读
原发性肝癌是全球高发病率的恶性肿瘤之一。手术切除是治疗原发性肝癌的首选手段,然而手术切除后复发率、转移率高,预后差是严重制约手术治疗远期疗效的重要因素。肝癌的转移是一个多步骤、多因素相互作用的复杂过程。近年来研究发现微转移是引起肿瘤复发和转移的根源,微转移的检测对肿瘤的准确分期、指导治疗、判断预后有重要意义,目前常用肝癌微转移灶检测标志物包括端粒酶、甲胎蛋白mRNA、MicroRNAs、上皮型钙黏素、CD44v6 mRNA和细胞角蛋白。本文从肝癌微转移灶的概念背景、标本来源、检测标志物、检测方法及相关临床意义等方面对肝癌微转移的研究进展进行综述,旨在探讨微转移灶检测在肝癌临床治疗及预后中的重要意义。
Primary liver cancer is one of the highest rates of malignancy in the world. Surgical resection is the first choice for the treatment of primary liver cancer. However, the recurrence rate, high metastasis rate and poor prognosis after surgical resection are the important factors that seriously restrict the long-term efficacy of surgical treatment. The metastasis of HCC is a complex process with multi-step and multi-factor interactions. In recent years, the study found that micrometastasis is the root cause of tumor recurrence and metastasis. The detection of micrometastases is of important significance for accurate staging of tumor, guiding treatment and prognosis. At present, micrometastasis markers of liver cancer include telomerase, Protein mRNA, MicroRNAs, E-cadherin, CD44v6 mRNA and cytokeratin. This review summarizes the research progress of the micrometastasis of liver cancer from the conceptual background of liver cancer micrometastasis, the source of specimens, the detection markers, the detection methods and the related clinical significance so as to investigate the clinical significance of micrometastasis detection in the treatment and prognosis of liver cancer Significance.