Induced pluripotent stem cells for therapy personalization in pediatric patients:Focus on drug-induc

• 作 者: Elena Genova Federica Cavion M
• 机 构: PhDSchoolinReproductionandDevelopmentSciences,DepartmentofLifeSciences,InstituteforMaternalandChildH
• 出 处: 世界干细胞杂志:英文版(电子版)
• 发表日期: 2019年12期
• 关键词: Induced pluripotent stem cells ORGANOIDS Adverse drug reactions Intestinal TOXIC
• 基金项目: Italian Ministry of Health(IRCCS Burlo Garofolo),No.RC 7_2014,No.RC 10_2019,progetto fondo di ricerca Ateneo,Universitàdi Trieste,No.FRA2018

Adverse drug reactions(ADRs)are major clinical problems,particularly in special populations such as pediatric patients.Indeed,ADRs may be caused by a plethora of different drugs leading,in some cases,to hospitalization,disability or even death.In addition