Inhibitory effect of Sumu (Lignum Sappan) plus Fuzi (Radix Aconiti Lateralis Praeparata) on a lung c

• 作 者: Zhang Hewei Ma Shuran Tian Tian Xu Ya Zhao Dandan Wang Tong Hou Chunying Zhang Shujing
• 机 构: College of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, Chi
• 出 处: 中医杂志（英文版）
• 发表日期: 2018年2期
• 关键词: Carcinoma Lewis lung Blood stasis Sumu (Lignum Sappan) Fuzi (Radix Aconiti Later

OBJECTIVE:To investigate the inhibitory effect of Sumu (Lignum Sappan) plus Fuzi (Radix Aconiti Lateralis Praeparata) (SF) on the growth and metastasis of Lewis lung carcinoma.METHODS:A lung carcinoma model was established by subcutaneously inoculating Lewis lung carcinoma cells into C57BL/6 mice.The mice were randomly divided into four groups of 13 mice (control,low-dose,moderate-dose,and high-dose),and gavaged once-daily for 21 consecutive days.The rates of tumor inhibition,metastasis,and metastasis inhibition were observed.The differential expressions of sP-selectin and vascular endothelial growth factor C (VEGFC) were compared between the treatment groups and the control group.RESULTS:The tumor weights differed significantly between the treatment groups and the control group (P ＜ 0.05).Administration of SF in the moderate-dosage and low-dose groups significantly inhibited the expression of sP-selectin and VEGFC (both P ＜ 0.05),suggesting anti-tumor activity.CONCLUSION:SF can inhibit the growth and metastasis of Lewis lung carcinoma.