论文部分内容阅读
目的 探讨胃蛋白酶原C(PGC)在不同胃疾病中的动态表达情况并对其在胃癌前疾病及胃癌诊断中的价值作出评价。方法 采用免疫组织化学染色检测 4 2 4例胃黏膜标本中PGC的表达情况。结果 PGC抗原在 5 4例正常胃黏膜中全部阳性表达 (10 0 % ) ,在 12 4例胃癌中表达率显著下降 (2 4 % ) ,从浅表性胃炎或胃糜烂溃疡到萎缩性胃炎或异型增生再到胃癌 ,PGC阳性表达率依次逐渐下降 ,差异有非常显著意义 (P <0 0 1)。结论 PGC抗原的表达与胃黏膜细胞恶性程度呈负相关 ,与胃疾病的发生发展有良好的相关性。PGC抗原对于胃癌前疾病的诊断具有较高的灵敏度和特异度 ,对于癌前疾病的诊断 ,对胃癌筛查、早期诊断具有一定的参考价值。
Objective To investigate the dynamic expression of pepsinogen C (PGC) in different gastric diseases and to evaluate its value in the diagnosis of gastric precancerous diseases and gastric cancer. Methods Immunohistochemical staining was used to detect the expression of PGC in 424 gastric mucosa specimens. Results The positive rate of PGC antigen was 100% in 54 normal gastric mucosa tissues and significantly decreased in 124 gastric cancer tissues (24%). The rate of superficial gastritis or gastric erosion ulcer to atrophic gastritis Dysplasia and then to gastric cancer, PGC positive expression rate gradually decreased, the difference was very significant (P <0.01). Conclusion The expression of PGC antigen is negatively correlated with the malignant degree of gastric mucosal cells and has a good correlation with the occurrence and development of gastric diseases. PGC antigen for the diagnosis of gastric cancer has a high sensitivity and specificity, for the diagnosis of precancerous lesions, gastric cancer screening, early diagnosis has a certain reference value.