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一般认为,胰岛样生长因子I(IGF-I)参 与人体骨肉瘤细胞增殖。存在于血液中的IGF-I大多由肝脏产生,IGF-I基因转录受生长激素(GH)调节。为研究拮抗剂对人体骨肉瘤细胞增殖的影响和作用,合成了各种不同效价的生长激素释放激素(GH-RH)拮抗剂,其中包括[Ib_u~0,D-Arg~2,Phe(4CI)~6,Abu~5,Nle~(27)]hGH-RH(1-28-Agm,又称MZ-4-71。将人体骨肉瘤细胞SK-ES-1和MNNG/
It is generally believed that islet-like growth factor I (IGF-I) participates in the proliferation of human osteosarcoma cells. Most of the IGF-I present in the blood is produced by the liver, and IGF-I gene transcription is regulated by growth hormone (GH). In order to study the effect and effect of antagonists on human osteosarcoma cell proliferation, a variety of potent growth hormone releasing hormone (GH-RH) antagonists were synthesized, including [Ib_u~0, D-Arg~2, Phe ( 4CI) ~ 6, Abu ~ 5, Nle ~ (27)] hGH-RH (1-28-Agm, also known as MZ-4-71. Human osteosarcoma cells SK-ES-1 and MNNG /