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由于异氟醚可以降低脑氧代谢率(CMRO_2),维持脑血流量(CBF)不变而被选用为神轻外科手术麻醉。这种作用在脑缺血氧供给障碍时可能是有益的。因为氧化亚氨(N_2O)较单独应用异氟醚对心血管的有害作用及对呼吸的影响小而一直被认为是一种好的麻醉药,常用于辅助异氟醚麻做神经外科手术。但在人和动物大量研究证明,N_2O 可以增加CBF、CMRO_2和颅内压,并在缺血时使脑能量负荷降低。也有报道N_2O 有对抗巴比妥类和苯二氮(艹卓)类药的脑保护作用,增加CMRO_2。为了评价在中度和严重不完全性脑缺血时单独应用N_2O 或
Isoflurane was chosen as a minimally invasive surgical anesthetic because it reduced cerebral oxygen metabolism (CMRO_2) and maintained CBF. This effect may be beneficial in the context of cerebral ischemia and oxygen supply disorders. Because nitrous oxide (N 2 O) than the separate application of isoflurane on the cardiovascular effects of cardiovascular and respiratory effects of small and has always been considered a good anesthetic, commonly used in the auxiliary isoflurane anesthesia for neurosurgery. However, a large number of studies in humans and animals have demonstrated that N 2 O can increase CBF, CMRO 2 and intracranial pressure and decrease brain energy load during ischemia. It has also been reported that N 2 O has a protective effect against barbiturates and benzodiazepines and increases CMRO_2. In order to evaluate the use of N2O alone or in the case of moderate and severe incomplete cerebral ischemia