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研究幽门螺杆菌(HELICOBACTER PYLORI)感染、突变型 P53基因表达与胃癌的关系,以及胃癌时 HP感染与突变型P53基因表达的关系.方法:用快速尿素酶试验和ELISA法检测HP和HP抗体,用免疫组化方法测定突变型P53蛋白.结果:胃癌和胃癌前病变组HP阳性率高于其它组(P＜0.05),而胃癌组HP阳性率和胃癌前病变组无显著差异(P＞0.05),胃癌组突变型 P53蛋白阳性率高于胃癌前病变组(P＜0.05),胃癌中 HP阳性者突变型 P53蛋白阳性率高于 HP阴性者(P＜0.05).结论:胃癌的发生和HP感染、突变型P53基因表达有关,胃癌时HP感染与突变型P53基因表达也存在相关性.“,”Objective: To investigate the relation ship between helicobacter pylon(HP), mutant p53 expression in gastric cancer. Methods: Using immediate urease test and ELISA to detect HP, immuno histochemical staining to detect mutan p53 protein. Results: The positive rate of HP in gastric cancer and gasric precancerous conditions is higher than that of the other (P0.05). The positive rate of mutant p53 protein in gastric cancer is higher than in precancerous conditions (P<0.05) HP positive gastric cancer has a higher positive rate of mutan p53 protein than HP negative gastric cancer (p<0.05). Conclusion: HP inflammation and mutant p53 expression have a role in the development of gastric cancer. In gastric cancer HP inflammation has a connection with the expression of mutant p53 gene.