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我们的资料表明樟柳碱影响近记忆,而记忆与胆碱能系统密切相关。本文在大白鼠身上观察了樟柳碱对脑组织乙酰胆碱(ACh)含量的影响,发现在注射樟柳碱后1小时及48小时,海马、大脑皮层及尾核脑组织Ach含量均下降,且尤其对海马的影响为著及持续较久。材料与方法:本文所选用的大白鼠,均为雄性共30只,体重200～300克,随机分为实验组20只及对照组10只。实验组均腹腔注射樟柳碱,剂量为1mg/kg,用生理盐水配制成0.1mg/ml的溶液。对照组注射等容积的生理盐水。实验组分为A组及B组,分
Our data suggest that anisodine affects near memory and memory is closely related to the cholinergic system. In this paper, we observed the effect of anisodine on acetylcholine (ACh) in brain tissue of rats, and found that the contents of Ach in hippocampus, cerebral cortex and caudate nucleus decreased at 1 h and 48 h after injection of anisodine and especially The impact on the hippocampus lasts longer and longer. MATERIALS AND METHODS: Thirty rats, all male, weighing 200-300g, were randomly divided into experimental group (n = 20) and control group (n = 10). The experimental group were peritoneal injection of anisodine, a dose of 1mg / kg, formulated with saline 0.1mg / ml solution. The control group was injected with normal saline. Experimental group A and group B, points